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- Title
Clinical Characteristics and Predictors of Short-Term Outcome in Mexican Adult Patients with Guillain-Barré Syndrome.
- Authors
Ruiz-Sandoval, Jose; Salvatella-Gutiérrez, Ana; López-Valencia, Germán; Chiquete, Erwin; Ruiz-Herrera, Vida; Pérez-Gómez, Héctor; Adrián, Miranda-García; Jiménez-Ruiz, Amado; Rodríguez-Hinojosa, Jorge; Quintero-Reyes, Ángeles; González-Jaime, José; Villaseñor Cabrera, Teresita; Ruiz-Sandoval, Jose Luis; Salvatella-Gutiérrez, Ana Paola; Pérez-Gómez, Héctor Raúl; Adrián, Miranda-García Luis; González-Jaime, José de Jesús; Villaseñor Cabrera, Teresita de Jesús
- Abstract
<bold>Background: </bold>Information regarding the clinical presentation and outcome of Guillain-Barré Syndrome (GBS) in adults from Latin America is limited.<bold>Objective: </bold>To identify clinical characteristics and short-term outcome predictors in adult Mexican patients with GBS.<bold>Patients and Methods: </bold>We included adult patients with clinical and electrophysiological data with confirmed GBS, admitted to a tertiary hospital in Western Mexico, from January 2002 to February 2011. A good outcome at hospital discharge was considered if patients had a Hughes score of 0-2 and at 3 and 6 months, a Hughes score of 0-1.<bold>Results: </bold>A total of 115 patients were analyzed (68% men, mean age 44 years old, range 18-84). Previous infection occurred in 63% of cases. Descendent pattern of weakness was observed in 40 (35%) patients. GBS subtypes were: acute motor axonal neuropathy in 31%, acute inflammatory demyelinating polyneuropathy in 29%, sensory axonal neuropathy (AMSAN) in 18%, and equivocal in 22%. A total of 73 (63%) patients received induction therapy: 50 (68%) received plasmapheresis and 13 (18%) received intravenous immunoglobulin (IVIG). In-hospital mortality occurred in 14 (12%) patients. Early gait complaints and emergency room admission with mild Hughes score (0-2) were predictors for a good outcome at hospital discharge (P < 0.05); meanwhile, age >75 years; dysarthria and higher Hughes score were associated with a poor outcome(P < 0.05).<bold>Conclusions: </bold>Axonal pattern, motor involvement, and the descendent pattern of presentation were the main clinical GBS findings in our cohort. Higher Hughes scale scores at hospital admission were a strong predictor for a bad outcome at hospital discharge and short-term follow-up, independently of treatment type or in-hospital management. GBS in Mexico still carries considerable mortality.
- Subjects
MEXICO; GUILLAIN-Barre syndrome; MEXICANS; FORECASTING; POLYNEUROPATHIES; MOTOR neuron diseases; HOSPITAL admission &; discharge
- Publication
Neurology India, 2021, Vol 69, Issue 1, p107
- ISSN
0028-3886
- Publication type
journal article
- DOI
10.4103/0028-3886.310063