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- Title
A Series of 62 Skull Base Chordomas in Pediatric and Adolescent Patients: Clinical Characteristics, Treatments, and Outcomes.
- Authors
Bai, Jiwei; Zhang, Shuheng; Zhai, Yixuan; Wang, Shuai; Li, Mingxuan; Li, Chuzhong; Zhao, Peng; Geng, Sumin; Gui, Songbai; Zhang, Yazhuo
- Abstract
<bold>Background: </bold>Skull base chordomas in pediatric and adolescent patients are rare and challenging for surgeons.<bold>Objective: </bold>Well-specified diagnosis and treatment are of great value for the long-term control of chordoma. This study summarizes well-followed pediatric and adolescent chordoma (PAC) patients treated in a single Asian center.<bold>Methods: </bold>PAC patients were enrolled. Data collected included clinical presentation, tumor volume, texture, surgical approach, pathology, complications, adjuvant radiotherapy (RT), and long-term outcomes.<bold>Results: </bold>Sixty-two patients were identified from a total of 516 skull base chordoma patients (12%). Diplopia was the most prominent complaint (30%). The craniocervical junction area was the most common location (41.8%) and had the highest proportion of large tumors. The gross total resection (GTR) rate was 20.3%. The GTR rate was lowest for tumors located in the craniocervical junction area. Thirty-eight cases experienced surgical complications. Of note, there was a significant difference in the complication rate between endoscopic approaches (22.7%) and open approaches (57.9%) (P = 0.005). The mean follow-up was 66.5 months. The GTR group showed better survival compared with the non-GTR group (P = 0.043). Metastases were found in two cases. No significant difference in the overall survival (OS) time was found between the group with RT and the group without RT (P = 0.559).<bold>Conclusions: </bold>A higher proportion of PAC patients than previously reported exist in the population in Asia, and the metastatic rate is lower. GTR predicts excellent long-term control of the disease. RT should be considered on an individual basis.
- Subjects
ASIA; GERM cell tumors; SKULL; RETROSPECTIVE studies; TREATMENT effectiveness; SKULL tumors; LONGITUDINAL method
- Publication
Neurology India, 2020, Vol 68, Issue 5, p1030
- ISSN
0028-3886
- Publication type
journal article
- DOI
10.4103/0028-3886.294548