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- Title
Chlorotrimethylsilane-Promoted Condensation of Ketones and Aminoazoles.
- Authors
Ryabukhin, Sergey V.; Naumchik, Vasiliy S.; Grygorenko, Oleksandr O.; Tolmachev, Andrey A.
- Abstract
Chlorotrimethylsilane-promoted reaction of ketones and aminoazoles ( i.e., 3-amino-1,2,4-triazoles, 5-aminotetrazole) at 2 : 1 ratio resulted in the formation of 4,5-dihydroazolo[1,5 - a]pyrimidine derivatives as the single regioisomers in 35 - 71% yields. In the case of tert-butylmethylketone and 5-aminotetrazole as the starting materials, the solvent (dimethylformamide) entered the reaction instead of the second ketone molecule.
- Subjects
METHYLSILANE; CONDENSATION reactions; KETONES; AZOLES; RING formation (Chemistry); PYRIMIDINE derivatives; ORGANIC solvents
- Publication
Journal of Heterocyclic Chemistry, 2012, Vol 49, Issue 5, p1147
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.972