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- Title
Elastic properties of woven bone: effect of mineral content and collagen fibrils orientation.
- Authors
García-Rodríguez, J.; Martínez-Reina, J.
- Abstract
Woven bone is a type of tissue that forms mainly during fracture healing or fetal bone development. Its microstructure can be modeled as a composite with a matrix of mineral (hydroxyapatite) and inclusions of collagen fibrils with a more or less random orientation. In the present study, its elastic properties were estimated as a function of composition (degree of mineralization) and fibril orientation. A self-consistent homogenization scheme considering randomness of inclusions' orientation was used for this purpose. Lacuno-canalicular porosity in the form of periodically distributed void inclusions was also considered. Assuming collagen fibrils to be uniformly oriented in all directions led to an isotropic tissue with a Young's modulus $$E = 1.90$$ GPa, which is of the same order of magnitude as that of woven bone in fracture calluses. By contrast, assuming fibrils to have a preferential orientation resulted in a Young's modulus in the preferential direction of 9-16 GPa depending on the mineral content of the tissue. These results are consistent with experimental evidence for woven bone in foetuses, where collagen fibrils are aligned to a certain extent.
- Subjects
OSTEITIS deformans; OSTEOBLASTS; REGULATION of biomineralization; ELASTIC modulus measurement; FETAL development; PATIENTS; PHYSIOLOGY
- Publication
Biomechanics & Modeling in Mechanobiology, 2017, Vol 16, Issue 1, p159
- ISSN
1617-7959
- Publication type
Article
- DOI
10.1007/s10237-016-0808-z