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- Title
Rhodium(III)-Catalyzed Intramolecular Redox-Neutral Annulation of Tethered Alkynes: Formal Total Synthesis of (±)-Goniomitine.
- Authors
Zhou, Bing; Du, Juanjuan; Yang, Yaxi; Li, Yuanchao
- Abstract
A RhIII-catalyzed intramolecular redox-neutral atom-economic annulation of a tethered alkyne has been developed to efficiently construct 2-amidealkyl indoles with completely reversed regioselectivity by a CH activation pathway. Furthermore, using the RhIII-catalyzed CH activation/annulation as a key step, a one-pot synthesis of pyrido[1,2-a]indoles has also been developed and applied to a highly efficient formal total synthesis of (±)-goniomitine.
- Subjects
ALKYNES; RHODIUM; CHEMICAL synthesis; CARBON-hydrogen bonds; CARBOLINES
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 40, p12768
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201403973