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- Title
New designed DNA light switch Ruthenium complexes as DNA photocleavers and Topoisomerase I inhibitors.
- Authors
Liu, Xue‐Wen; Xiao, Yang; Peng, Wei‐Gen; Zhao, Li‐Jin; Shen, You‐Ming; Zhang, Song‐Bai; Lu, Ji‐Lin
- Abstract
Two ruthenium complexes containing a new ligand phipz (phipz = 2‐(1,10‐phenanthroline)‐1H‐imidazo[4,5‐b]phenazine) were designed and synthesized. These complexes were found to inhibit the DNA supercoiled relaxation mediated by topoisomerase I (topo I), cleave DNA under irradiation and bind to calf thymus DNA through intercalative mode. Furthermore, complex <bold>2</bold> shows higher photocleavage activity, topo I inhibition activity and DNA affinity than complex <bold>1</bold>. Additionally, introduction of phenazine unit may be the reason that two complexes exhibit DNA ‘light switch’ behavior. The present work shows that two complexes might be potential as new DNA ‘light switches’, DNA photocleavers and topo I inhibitors.
- Subjects
COMPLEX compounds synthesis; METAL complexes; RUTHENIUM compounds; DNA topoisomerase I; LIGANDS (Chemistry); CHEMICAL relaxation
- Publication
Applied Organometallic Chemistry, 2018, Vol 32, Issue 4, p1
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.4231