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- Title
Palladium-catalyzed highly selective intramolecular bromoamination of alkenes: Efficient synthesis of substituted pyrrolidines.
- Authors
Zhang, Jingfang; Wang, Xie; Liu, Yulong; Wang, Xiaoyun; He, Wei
- Abstract
A new method has been developed for the preparation of substituted pyrrolidines by the palladium-catalyzed intramolecular bromoamination of substituted aminoalkenes. The catalytic system and reaction conditions used for this transformation have been fully optimized. Notably, this reaction exhibits excellent selectivity, affording the pyrrolidine products as single 5-exo-bromoalkylpyrrolidines in excellent yields. Furthermore, this reaction occurs at room temperature under mild conditions, reaching completion within 1 h.
- Subjects
PALLADIUM catalysts; INTRAMOLECULAR catalysis; AMINATION; ALKENE synthesis; PYRROLIDINE
- Publication
Applied Organometallic Chemistry, 2017, Vol 31, Issue 6, pn/a
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.3631