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- Title
Differentiation of focal indeterminate marrow abnormalities with multiparametric MRI.
- Authors
Baik, Jun Seung; Jung, Joon‐Yong; Jee, Won‐Hee; Chun, Chang‐Woo; Kim, Sun Ki; Shin, Seung Han; Chung, Yang Guk; Jung, Chan‐Kwon; Kannengiesser, Stephan; Sohn, YoHan; Jung, Joon-Yong; Jee, Won-Hee; Chun, Chang-Woo; Jung, Chan-Kwon
- Abstract
<bold>Purpose: </bold>To explore magnetic resonance imaging (MRI) parameters from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), multiecho Dixon imaging (ME-Dixon), and dynamic contrast-enhanced imaging (DCE) for differentiating focal indeterminate marrow abnormalities MATERIALS AND METHODS: Forty-two patients with 14 benign and 28 malignant focal marrow abnormalities were included. The following were independently analyzed by two readers: signal intensity (SI), contour, and margin on conventional MR images; SI on b-800 images (SIb-800 ), apparent diffusion coefficient (ADC), IVIM parameters (Dslow, Dfast , and f), fat fraction (Ff), and DCE parameters (time-to-signal intensity curve pattern, iAUC, Ktrans , kep , and ve ). The MR characteristics and parameters from benign and malignant lesions were compared with a chi-squared test and the Mann-Whitney U-test, respectively. The area under receiver operating characteristic (ROC) curves (AUC) of each sequence were also compared. Interobserver agreements were assessed with Cohen's κ, and intraclass correlation coefficient (ICC).<bold>Results: </bold>ADC, Dslow , and Ff demonstrated a significant difference between benign and malignant marrow abnormalities for both readers (P < 0.001). SIb-800 and perfusion-related parameters from IVIM-DWI and DCE were not significantly different between the two groups (P = 0.145, 0.439, and 0.337 for reader 1, P = 0.378, 0.368, and 0.343 for reader 2, respectively). The AUCs of ADC, Dslow , and Ff were significantly higher for differentiating indeterminate marrow abnormalities in both readers (P < 0.001). Interobserver agreements were substantial in SIb-800 , and ICCs were almost perfect for ADC, Dslow , f, and Ff, and substantial for iAUC, kep , Ktrans , ve , and Dfast .<bold>Conclusion: </bold>ADC, Dslow , and Ff may provide information for differentiating focal indeterminate abnormalities.<bold>Level Of Evidence: </bold>3 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:49-60.
- Publication
Journal of Magnetic Resonance Imaging, 2017, Vol 46, Issue 1, p49
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25536