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- Title
Early response to chemoradiotherapy for nasopharyngeal carcinoma treatment: Value of dynamic contrast-enhanced 3.0 T MRI.
- Authors
Zheng, Dechun; Chen, Yunbin; Liu, Xiangyi; Chen, Ying; Xu, Luying; Ren, Wang; Chen, Weibo; Chan, Queenie
- Abstract
Purpose To prospectively evaluate the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) value for predicting early nasopharyngeal carcinoma (NPC) chemoradiotherapy (CRT) response. Materials and Methods Forty-two patients with advanced NPC were recruited and received three DCE-MRI exams before treatment (Pre-Tx), as well as 3 days (Day 3-Tx) and 40 days (Day 40-Tx) after chemotherapy initiation (two neoadjuvant chemotherapy cycles, NAC). We used DCE-Tool to measure primary tumor kinetic parameters ( Ktrans, Kep, ve, and vp) using the extended Tofts model. Kinetic parameters and corresponding changes were compared between responders and nonresponders after NAC or CRT treatment using Student's t or Mann-Whitney U tests. Results Response to two NAC cycles correlated with short-term local control ( P = 0.01). Compared to the nonresponder group, the responder group presented with significantly larger Δ Ktrans(0-3), Δ Kep(0-3), and Δ vp(0-3) values after NAC ( P < 0.05). The complete response group after CRT exhibited significantly lower Ktrans(Day 40-Tx) and larger Δ Ktrans(0-3) values than the residual group ( P = 0.05). High sensitivity (range: 74.1%-90%) and moderate-to-high specificity (range: 50%-84.3%) distinguished nonresponders from responders grouping after NAC or CRT, with diagnostic efficiency ranging from 69.3%-88%. Conclusion Our study showed kinetic parameter changes earlier after chemotherapy were potential markers for NPC patients receiving CRT therapy following NAC. J. Magn. Reson. Imaging 2015;41:1528-1540. © 2014 Wiley Periodicals, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2015, Vol 41, Issue 6, p1528
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.24723