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- Title
Association between FSAP 1601G > A polymorphism and venous thromboembolism risk: A meta-analysis.
- Authors
Da, Li; Jiahui, Zhao; Xiaoqiang, Li
- Abstract
Objective: Previous several studies have shown that factor VII-activating protease (FSAP) gene 1601G>A polymorphism is related to the occurrence of venous thromboembolism, but the results are inconsistent and controversial. Therefore, we conducted a meta-analysis to explore the association between FSAP 1601G>A polymorphism and venous thromboembolism susceptibility. Methods: We managed a systematic literature search through Pubmed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases to collect research data related to FSAP gene 1601G>A polymorphism and susceptibility to venous thromboembolism published before May 2019. Data analysis was performed through Revman 5.3 and Stata 12.0 software, the pooled odd ratios and 95% confidence intervals were calculated. Additionally, the sensitivity analysis and publication bias assessment were also performed. Results: A total of seven case–control studies were included and evaluated, including 2411 venous thromboembolism cases and 2850 controls. The meta-analysis results revealed that the FSAP 1601G>A mutation is associated with venous thromboembolism risk, and statistically significance was observed under three genetic comparison models (A: G, odds ratio: 1.33, 95% confidence interval: 1.07–1.66; GA: GG, odds ratio: 1.34, 95% confidence interval: 1.06–1.68; and GA + AA: GG, odds ratio: 1.33, 95% confidence interval: 1.06–1.66). Conclusion: This study demonstrated that the FSAP 1601G>A polymorphism may be associated with venous thromboembolism susceptibility.
- Subjects
THROMBOEMBOLISM risk factors; BLOOD coagulation factors; DISEASE susceptibility; GENETIC polymorphisms; MEDICAL information storage &; retrieval systems; MEDLINE; META-analysis; ONLINE information services; VEINS; SYSTEMATIC reviews; DATA analysis
- Publication
Phlebology, 2020, Vol 35, Issue 5, p345
- ISSN
0268-3555
- Publication type
Article
- DOI
10.1177/0268355519881604