We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The role of serum basic fibroblast growth factor, estradiol and urine basic fibroblast growth factor in differentiating infantile haemangiomas from vascular malformations.
- Authors
Yang, X. J.; Jiang, Y. H.; Zheng, J. W.; Hong, L.; Zhou, Q.; Qin, Z. P.
- Abstract
Objective: To investigate the role of serum basic fibroblast growth factor (bFGF), estradiol (E2) and urine bFGF in differentiating infantile haemangiomas from vascular malformations. Method: Between October 2007 and January 2009, 97 patients with haemangiomas and 25 patients with vascular malformations who had not been treated previously were included in this prospective study. Forty-eight patients with cleft lip and/or palate were selected as controls. The age of all subjects ranged from 1 to 30 months. The serum and urine levels of bFGF were determined by enzyme-linked immunosorbent assay (ELISA). The serum levels of E2 were examined via radioimmunoassay. All data were analysed with SPSS 11.5 software package. Results: The concentration of serumand urine bFGFwas significantly different among the three groups (haemangiomas, vascular malformations and controls) (P = 0.027, P = 0.001). Significantly different urine bFGF levels were found in patients with proliferating and involuting haemangiomas (P = 0.04). The serum E2 levels were significantly higher in patients with haemangiomas than vascularmalformations (P = 0.001) and controls (P = 0.001). Conclusion: Serum bFGF and E2 as well as urine bFGF can be used to supplement the clinical diagnosis of congenital vascular anomalies. Urine bFGF combined with serum E2 may be the most potential markers for diagnosing haemangiomas and determining the proliferating stage of haemangiomas.
- Subjects
CHINA; HEART abnormality diagnosis; ACADEMIC medical centers; ANALYSIS of variance; CLEFT lip; CLEFT palate; ENZYME-linked immunosorbent assay; ESTRADIOL; FIBROBLASTS; GROWTH factors; HEART abnormalities; HEMANGIOMAS; LONGITUDINAL method; RADIOIMMUNOASSAY; RESEARCH funding; T-test (Statistics); CONTROL groups; DATA analysis software; CHILDREN; DIAGNOSIS
- Publication
Phlebology, 2011, Vol 26, Issue 5, p191
- ISSN
0268-3555
- Publication type
Article
- DOI
10.1258/phleb.2010.010020