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- Title
Decreased serum level of IL-21 in new-onset systemic lupus erythematosus patients.
- Authors
Pan, Hai-Feng; Wu, Guo-Cui; Fan, Yin-Guang; Leng, Rui-Xue; Peng, Hui; Zhou, Mo; Li, Bao-Zhu; Zhu, Yan; Tao, Jin-Hui; Li, Xiang-Pei; Ye, Dong-Qing
- Abstract
This study aims to investigate the serum IL-21 levels in systemic lupus erythematosus (SLE) and its relations with clinical and laboratory features. Fifty-seven patients with SLE and 30 healthy volunteers were recruited in the current study. Serum IL-21 levels were detected by enzyme-linked immunosorbent assay. Statistical analyses were performed by SPSS 10.01. Results showed that IL-21 levels were significantly decreased in the serum of patients with SLE compared with controls ( P = 0.026). There was no significant difference regarding serum IL-21 level between SLE patients with nephritis and those without nephritis ( P = 0.066); no significant difference was found between less active SLE and more active SLE ( P = 0.588). The presence of anemia was associated with low serum IL-21 levels ( P = 0.030) in SLE patients. In summary, decreased serum level of IL-21 and its association with anemia indicate a possible role of IL-21 in human SLE. However, further studies are needed to confirm this preliminary results.
- Subjects
SERUM; INTERLEUKIN-21; SYSTEMIC lupus erythematosus; VOLUNTEERS' health; ENZYME-linked immunosorbent assay; QUANTITATIVE research; COMPARATIVE studies; NEPHRITIS; PATIENTS
- Publication
Rheumatology International, 2013, Vol 33, Issue 9, p2337
- ISSN
0172-8172
- Publication type
Article
- DOI
10.1007/s00296-013-2724-1