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- Title
Variations and natural history of primary intraparenchymal lesions associated with neurofibromatosis type 2.
- Authors
Ishi, Yukitomo; Harada, Taisuke; Kameda, Hiroyuki; Okada, Hiromi; Yokota, Isao; Okamoto, Michinari; Sawaya, Ryosuke; Motegi, Hiroaki; Yamaguchi, Shigeru; Terasaka, Shunsuke; Kudo, Kohsuke; Fujimura, Miki
- Abstract
The study aimed to investigate the clinical implications and natural history of primary intraparenchymal lesions in patients with neurofibromatosis type 2. Radiological findings of 15 neurofibromatosis type 2 cases were retrospectively collected. Twenty-seven primary intraparenchymal lesions were observed in 7 out of 15 patients (47%). Cortical/subcortical T2 hyperintense lesions and enlarged Virchow–Robin spaces were the most common findings in five and four patients, respectively. During the follow-up period (median 84 months), one new primary intraparenchymal lesion was identified and increased lesions were observed in two cases on contrast-enhanced MRI. Surgical resection was performed in one case pathologically diagnosed with atypical meningioma. Twenty-five other lesions without contrast enhancement presented no apparent growth during follow-up. Although most primary intraparenchymal lesions are benign, a subset of cases would present newly developed or increased lesions on contrast-enhanced MRI. Careful monitoring is necessary for such cases, and pathological confirmation should be considered.
- Subjects
BRAIN tumor genetics; BRAIN tumor risk factors; TIME; RETROSPECTIVE studies; MAGNETIC resonance imaging; NEURAL development; BRAIN tumors; MENINGIOMA; DESCRIPTIVE statistics; CEREBRAL cortex abnormalities; STATISTICAL correlation; NEUROFIBROMATOSIS 2
- Publication
Neuroradiology, 2022, Vol 64, Issue 2, p393
- ISSN
0028-3940
- Publication type
Article
- DOI
10.1007/s00234-021-02809-5