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- Title
Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study.
- Authors
Hiroyuki Oka; Toru Akune; Shigeyuki Muraki; Yoshio En-Yo; Munehito Yoshida; Akihiro Saika; Satoshi Sasaki; Kozo Nakamura; Hiroshi Kawaguchi; Noriko Yoshimura
- Abstract
Abstract Background The present study sought to identify dietary nutrients associated with the prevalence of radiographic knee osteoarthritis (OA) in the Japanese elderly of a population-based cohort of the Research on Osteoarthritis Against Disability (ROAD) study. Methods From the baseline survey of the ROAD study, 719 participants ≥60 years of age (270 men, 449 women) of a rural cohort were analyzed. Dietary nutrient intakes for the previous 1 month were assessed by a self-administered brief diet history questionnaire. The radiographic severity at both knees was determined by the Kellgren/Lawrence (KL) system. Results The prevalence of knee OA of KL ≥2 was 70.8%. Age, body mass index, and female sex were positively associated with the prevalence. Among the dietary factors, only vitamin K intake was shown to be inversely associated with the prevalence of radiographic knee OA by multivariate logistic regression analysis. The presence of joint space narrowing of the knee was also inversely associated with vitamin K intake. The prevalence of radiographic knee OA for each dietary vitamin K intake quartile decreased with the increased intake. Conclusions The present cross-sectional study using a population-based cohort supports the hypothesis that low dietary vitamin K intake is a risk factor for knee OA. Vitamin K may have a protective role against knee OA and might lead to a disease-modifying treatment.
- Subjects
KNEE radiography; OSTEOARTHRITIS; VITAMIN K; DIETARY supplements; INGESTION; OLDER people; JAPANESE people; COHORT analysis; LOGISTIC regression analysis
- Publication
Journal of Orthopaedic Science, 2009, Vol 14, Issue 6, p687
- ISSN
0949-2658
- Publication type
Article
- DOI
10.1007/s00776-009-1395-y