We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Molecular Magnetic Resonance Imaging of Lung Fibrogenesis with an Oxyamine-Based Probe.
- Authors
Waghorn, Philip A.; Jones, Chloe M.; Rotile, Nicholas J.; Koerner, Steffi K.; Ferreira, Diego S.; Chen, Howard H.; Probst, Clemens K.; Tager, Andrew M.; Caravan, Peter
- Abstract
Fibrogenesis is the active production of extracellular matrix in response to tissue injury. In many chronic diseases persistent fibrogenesis results in the accumulation of scar tissue, which can lead to organ failure and death. However, no non-invasive technique exists to assess this key biological process. All tissue fibrogenesis results in the formation of allysine, which enables collagen cross-linking and leads to tissue stiffening and scar formation. We report herein a novel allysine-binding gadolinium chelate (GdOA), that can non-invasively detect and quantify the extent of fibrogenesis using magnetic resonance imaging (MRI). We demonstrate that GdOA signal enhancement correlates with the extent of the disease and is sensitive to a therapeutic response.
- Subjects
LUNG disease diagnosis; LUNGS; EXTRACELLULAR matrix; BIOACCUMULATION; GADOLINIUM chelates; MAGNETIC resonance imaging
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 33, p9957
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201704773