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- Title
Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Genus Acacia.
- Authors
Batiha, Gaber El-Saber; Akhtar, Nosheen; Alsayegh, Abdulrahman A.; Abusudah, Wafaa Fouzi; Almohmadi, Najlaa Hamed; Shaheen, Hazem M.; Singh, Thakur Gurjeet; De Waard, Michel
- Abstract
Plants are a promising source of bioactive compounds that can be used to tackle many emerging diseases both infectious and non-infectious. Among different plants, Acacia is a very large genus and exhibits a diverse array of bioactive agents with remarkable pharmacological properties against different diseases. Acacia, a herb found all over the world, contains approximately more than 1200 species of the Fabaceae family. In the present review, we have collected detailed information on biochemical as well as pharmacological properties. The data were retrieved using different databases, such as Elsevier, PubMed, Science Direct, Google Scholar, and Scopus, and an extensive literature survey was carried out. Studies have shown that Acacia possesses several secondary metabolites, including amines, cyanogenic glycosides, flavonoids, alkaloids, seed oils, cyclitols, fluoroacetate, gums, non-protein amino acids, diterpenes, fatty acids, terpenes, hydrolyzable tannins, and condensed tannins. These compounds exhibit a wide range of pharmaceutical applications such as anti-inflammatory, antioxidant, antidiarrheal, antidiabetic, anticancer, antiviral, liver protective effects, and so on. Thus, the literature shows the tremendous phytochemical impact of the genus Acacia in medicine. Overall, we recommend that more research should be conducted on the medicinal value and isolation and purification of the effective therapeutic agents from Acacia species for the treatment of various ailments.
- Subjects
TANNINS; BIOACTIVE compounds; ACACIA; EMERGING infectious diseases; PHARMACOKINETICS; METABOLITES; LOCUST bean gum
- Publication
Molecules, 2022, Vol 27, Issue 21, p7340
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27217340