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- Title
Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy.
- Authors
Fuloria, Shivkanya; Sekar, Mahendran; Khattulanuar, Farrah Syazana; Gan, Siew Hua; Rani, Nur Najihah Izzati Mat; Ravi, Subban; Subramaniyan, Vetriselvan; Jeyabalan, Srikanth; Begum, M. Yasmin; Chidambaram, Kumarappan; Sathasivam, Kathiresan V.; Safi, Sher Zaman; Wu, Yuan Seng; Nordin, Rusli; Maziz, Mohammad Nazmul Hasan; Kumarasamy, Vinoth; Lum, Pei Teng; Fuloria, Neeraj Kumar
- Abstract
Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R2-viniferin (vitisin B). All of these forms exhibit a range of important biological activities and, therefore, have several possible applications in clinical research and future drug development. In this review, we present a comprehensive literature search on the chemistry and biosynthesis of and the diverse studies conducted on viniferin, especially with regards to its anti-inflammatory, antipsoriasis, antidiabetic, antiplasmodic, anticancer, anti-angiogenic, antioxidant, anti-melanogenic, neurodegenerative effects, antiviral, antimicrobial, antifungal, antidiarrhea, anti-obesity and anthelminthic activities. In addition to highlighting its important chemical and biological activities, coherent and environmentally acceptable methods for establishing vinferin on a large scale are highlighted to allow the development of further research that can help to exploit its properties and develop new phyto-pharmaceuticals. Overall, viniferin and its derivatives have the potential to be the most effective nutritional supplement and supplementary medication, especially as a therapeutic approach. More researchers will be aware of viniferin as a pharmaceutical drug as a consequence of this review, and they will be encouraged to investigate viniferin and its derivatives as pharmaceutical drugs to prevent future health catastrophes caused by a variety of serious illnesses.
- Subjects
DRUG discovery; PLANT defenses; BIOSYNTHESIS; PHARMACOLOGY; DRUGS; ANTHELMINTICS; ANTIDIARRHEALS
- Publication
Molecules, 2022, Vol 27, Issue 16, p5072
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27165072