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- Title
The Novel Function of Unsymmetrical Chiral CCN Pincer Nickel Complexes as Chemotherapeutic Agents Targeting Prostate Cancer Cells.
- Authors
Qu, Jing-Jing; Shi, Lin-Lin; Wang, Yan-Bing; Yan, Jing; Shao, Tian; Hao, Xin-Qi; Wang, Jia-Xiang; Zhang, Hong-Yu; Gong, Jun-Fang; Song, Bing
- Abstract
We report that the pincer nickel complexes display prostate cancer antitumor properties through inhibition of cell proliferation. Notably, they display better antitumor properties than cisplatin. Mechanistic studies reveal that these pincer nickel complexes trigger cell apoptosis, most likely due to cell cycle arrest. Interestingly, these complexes also inhibit androgen receptor (AR) and prostate-specific antigen (PSA) signaling, which are critical for prostate cancer survival and progression. Our study reveals a novel function of pincer nickel complexes as potential therapeutic drugs in prostate cancer.
- Subjects
PROSTATE cancer; CANCER cells; NICKEL; PROSTATE-specific antigen; CANCER chemotherapy; CISPLATIN; CELL cycle
- Publication
Molecules, 2022, Vol 27, Issue 10, p3106
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27103106