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- Title
Dianthiamides A–E, Proline-Containing Orbitides from Dianthus chinensis.
- Authors
Lee, Jin Woo; Kim, Jun Gu; Han, Jae Sang; Cho, Yong Beom; Lee, Yu Jin; Lee, Dongho; Shin, Dae Hwan; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
- Abstract
Orbitides are plant-derived small cyclic peptides with a wide range of biological activities. Phytochemical investigation of the whole plants of Dianthus chinensis was performed with the aim to discover new bioactive orbitides. Five undescribed proline-containing orbitides, dianthiamides A–E (1–5), were isolated from a methanolic extract of Dianthus chinensis. Their structures were elucidated by extensive analysis of 1D and 2D NMR and HRESI–TOF–MS as well as ESI–MS/MS fragmentation data. The absolute configuration of the amino acid residues of compounds 1–5 was determined by Marfey's method. All compounds were tested for their cytotoxic activity, and dianthiamide A (1) exhibited weak activity against A549 cell line with IC50 value of 47.9 μM.
- Subjects
PINKS (Plants); AMINO acid residues; CYCLIC peptides
- Publication
Molecules, 2021, Vol 26, Issue 23, p7275
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26237275