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- Title
Antioxidant and Antiproliferative Activity of the Ethanolic Extract of Equisetum myriochaetum and Molecular Docking of Its Main Metabolites (Apigenin, Kaempferol, and Quercetin) on β-Tubulin.
- Authors
Olazarán-Santibañez, Fabián; Rivera, Gildardo; Vanoye-Eligio, Venancio; Mora-Olivo, Arturo; Aguirre-Guzmán, Gabriel; Ramírez-Cabrera, Mónica; Arredondo-Espinoza, Eder; Attanzio, Alessandro; Tesoriere, Luisa
- Abstract
Equisetum myriochaetum is a semi-aquatic plant found on riverbanks that is commonly used in traditional medicine as a diuretic agent. Additionally, the genus Equisetum stands out for its content of the flavonoid kaempferol, a well-known antiproliferative agent. Therefore, in this study, E. myriochaetum ethanolic extract was tested in vitro against a cervical cancer cell line (SiHa). Additionally, the antioxidative activity was evaluated through a 2,2-diphenyl-1-picrilhidrazil (DPPH) assay. Finally, a molecular docking analysis of apigenin, kaempferol, and quercetin on the active site of β-tubulin was performed to investigate their potential mechanism of action. All fractions of E. myriochaetum ethanolic extract showed antioxidative activity. Fraction 14 displayed an antiproliferative capacity with a half maximal inhibitory concentration (IC50) value of 6.78 μg/mL against SiHa cells.
- Subjects
MOLECULAR docking; APIGENIN; QUERCETIN; METABOLITES; EXTRACTS; CERVICAL cancer
- Publication
Molecules, 2021, Vol 26, Issue 2, p443
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26020443