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- Title
Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones.
- Authors
Fadeev, Alexander A.; Chagarovskiy, Alexey O.; Makarov, Anton S.; Levina, Irina I.; Ivanova, Olga A.; Uchuskin, Maxim G.; Trushkov, Igor V.; Gitsov, Ivan; Loska, Rafał
- Abstract
A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed. This method, based on the Corey–Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hydroxy-substituted cyclopropanes, which can serve as promising building blocks for the synthesis of various bioactive compounds.
- Subjects
CYCLOPROPANATION; KETONES; CYCLOPROPANE; BIOACTIVE compounds; CYCLOPROPANE derivatives
- Publication
Molecules, 2020, Vol 25, Issue 23, p5748
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25235748