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- Title
Potentially Bioaccessible Phenolics from Mung Bean and Adzuki Bean Sprouts Enriched with Probiotic—Antioxidant Properties and Effect on the Motility and Survival of AGS Human Gastric Carcinoma Cells.
- Authors
Świeca, Michał; Herok, Anna; Piwowarczyk, Katarzyna; Sikora, Małgorzata; Ostanek, Patryk; Gawlik-Dziki, Urszula; Kapusta, Ireneusz; Czyż, Jarosław; Pellati, Federica
- Abstract
Gastric digests from mung (MBS) and adzuki (ABS) bean sprouts enriched with probiotic Lactobacillus plantarum 299v were tested for their antioxidant potential, as well as antiproliferative and antimotility properties, in human stomach cancer cells (AGS). The digest of ABS contained quercetin and kaempferol derivates, while kaempferol and apigenin derivates were dominant in MBS. Compared to the controls, the probiotic-rich sprouts had a higher antioxidant potential—by 13% and 9%, respectively. Adzuki bean sprouts decreased the viability of AGS already at low concentrations (25% motility inhibitions). MBS and ABS displayed dose-independent cytostatic effects. The ABS extracts decreased the proliferation of AGS more effectively than the MBS extracts—0.2‰ ABS exerted c.a. 70% of inhibitions. Moreover, the phytochemicals from the probiotic-rich sprouts considerably reduced this activity. The increased vinculin level, the apoptotic shape of cell nuclei, and the reduced cell motility and proliferation indicate that the extracts exhibited cytostatic and cytotoxic activity.
- Subjects
SPROUTS; PHENOLS; BEANS; CELL morphology; CELL nuclei; MUNG bean
- Publication
Molecules, 2020, Vol 25, Issue 13, p2963
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25132963