We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.
- Authors
Yang, Jing-Hua; Wang, Xin-Yi; Zhou, Yi-Ping; Lu, Rong; Chen, Chin-Ho; Zhang, Meng-Han; Cheng, Yung-Yi; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung; Wang, Yun-Song
- Abstract
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.
- Subjects
ALKALOIDS; CARBAZOLE; VIRAL replication
- Publication
Molecules, 2020, Vol 25, Issue 1, p99
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25010099