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- Title
Evaluation of Transition Metal Complexes of Benzimidazole-Derived Scaffold as Promising Anticancer Chemotherapeutics.
- Authors
Hussain, Afzal; AlAjmi, Mohamed F.; Rehman, Md. Tabish; Khan, Azmat Ali; Shaikh, Perwez Alam; Khan, Rais Ahmad
- Abstract
Three new transition metal complexes, Cu(II) <bold>1</bold>, Co(II) <bold>2</bold>, and Zn(II) <bold>3</bold> with ligand “bimnap” derived from 1-methyl-2-aminobenzimidazole and 2-hydroxynapthaldehyde were synthesized and characterized. The structure of the ligand was determined by single X-ray crystallography. All the three complexes, <bold>1</bold>–<bold>3,</bold> were examined for the mode of interaction with biomolecule viz., calf thymus-DNA (CT-DNA) using various spectroscopic methods. The nuclease activity was performed against pBR322 DNA that exhibited concentration-dependent degradation of the nucleic acid. The mechanism of DNA cleavage was studied by the electrophoretic pattern in the presence of the radical scavengers. Also, the complexes <bold>1</bold>–<bold>3</bold> were analyzed for groove binding affinity. Moreover, in vitro cytotoxicities of the complexes <bold>1</bold>–<bold>3</bold> were tested against the five human cancer cell lines, i.e., HeLa, SK-MEL-1, HepG2, HT108, and MDA-MB 231. Also, the cell adhesion and migration properties upon treatment of cell lines with complexes <bold>1</bold>–<bold>3,</bold> and consequently, their cell death pathway via apoptosis and necrosis were analyzed. Further, complexes <bold>1</bold>–<bold>3</bold> were studied in vivo for their toxicities and tolerabilities in mice. In sum, the complexes <bold>1</bold>–<bold>3</bold> showed merits of an effective anticancer agent in cell lines–based study while minor side effects were observed in vivo.
- Subjects
METAL complexes; COMPLEXATION reactions; CANCER chemotherapy; ANTINEOPLASTIC agents; CRYSTALLOGRAPHY
- Publication
Molecules, 2018, Vol 23, Issue 5, p1232
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23051232