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- Title
Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity.
- Authors
Cheng Zhong; Deng Hu; Lian-Bing Hou; Lu-Yao Song; Ying-Jun Zhang; Yang Xie; Li-Wen Tian
- Abstract
A new triflavanoid, kandelin B-5 (1), was isolated from the rhizomes of Smilax china L., together with six known phenylpropanoid substituted flavan-3-ols (2-7), nine flavonoids (8-16), two stilbenoids (17, 18), and two other compounds (19, 20). The structure of compound 1 was determined on the basis of 1D, 2D NMR and HR-ESI-MS data, as well as chemical method. Compounds 2-5, 8-12, 15, 17, and 19 were evaluated for anti-inflammatory activity. Only compounds 10, 15 and 17 showed slightly IL-1β expression inhibitory activities on LPS induced THP-1 cells, with inhibition rate of 15.8%, 37.3%, and 35.8%, respectively, at concentration of 50 μg/mL.
- Subjects
PHENOLS; PLANT phenols; ANTI-inflammatory agents; PHENYLPROPANOIDS; FLAVONOIDS; NUCLEAR magnetic resonance spectroscopy; INTERLEUKIN-1; CELL lines
- Publication
Molecules, 2017, Vol 22, Issue 4, p515
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22040515