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- Title
Synthesis 1-Acyl-3-(2′-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs.
- Authors
Li-Ping Duan; Jia Xue; Li-Li Xu; Hao-Bing Zhang
- Abstract
A series of 1-acyl-3-(2′-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, ¹H-NMR and 13C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were evaluated in rats by an oral route. Among these compounds, at concentrations of 10 mg/kg of rat, compound (1-(2′-furanyl)acyl-3- (2′- aminophenyl) thiourea) (5h) produced the highest activity with 89.4% deparasitization. The present work suggests that 1-acyl-3-(2′-aminophenyl) thiourea derivatives may become useful lead compounds for anti-intestinal nematode treatment.
- Subjects
NIPPOSTRONGYLUS brasiliensis; THIOUREA; NEMATODES; INFRARED imaging; NUCLEAR magnetic resonance
- Publication
Molecules, 2010, Vol 15, Issue 10, p6941
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules15106941