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- Title
Hepatitis B virus infection assessed 3 to 18 years after vaccination in Cuban children and adolescents born to HBsAg-positive mothers.
- Authors
Rodríguez Lay, Licel de los Angeles; Bello Corredor, Marité; Montalvo Villalba, Maria; Chibás Ojeda, Annia; Sariego Frómeta, Susel; Diaz González, Manuel; Abad Lamoth, Yoandra; Sánchez Wong, Meilin; Sausy, Aurélie; Muller, Claude; Hübschen, Judith
- Abstract
Thirty-two participants, aged between 3-18 years, born to hepatitis B surface antigen (HBsAg)-positive mothers and vaccinated at birth were analyzed for hepatitis B virus (HBV) infection. Overall, 56% had anti-HB titers ≥10 IU/L; five were positive for antibodies to the core antigen (anti-HBc), and two of these were also positive for HBsAg/DNA. One of the HBsAg/anti-HBc double-negative children presented with an unusual occult infection (HBV DNA-positive). No known vaccine escape mutations were detectable. Our data suggest that the vaccine protected 93.8% of children in this high-risk group against chronic HBV infection. Occult infections should be considered even in countries with low endemicity and high vaccination coverage.
- Subjects
HEPATITIS B vaccines; CUBANS; VIRAL antibodies; SEROPREVALENCE; GENETIC mutation; HEPATITIS associated antigen; DISEASES
- Publication
Archives of Virology, 2017, Vol 162, Issue 8, p2393
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-017-3365-6