We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of Prostaglandin E[sub 1] on Hepatic Blood Flow in Conscious Dogs with Chronic Biliary Obstruction.
- Authors
Nimura, Y.; Kanda, H.; Uematsu, T.; Kitagawa, Y.; Kamiya, S.; Watanabe, T.; Machiki, Y.
- Abstract
To evaluate the effects of prostaglandin E[sub 1] (PGE[sub 1] ) on the hepatic circulation in cholestasis, hepatic arterial blood flow (HAF), portal venous blood flow (PVF), cardiac output, and heart rate during PGE[sub 1] infusions were investigated before and 2 weeks after biliary obstruction in conscious dogs by a transit-time ultrasonic flowmeter. In the control period, HAF and PVF increased dose dependently with the infusion of PGE[sub 1] from 0.05 to 0.5 µg/kg/min. During the biliary obstruction period, a lower dose of PGE[sub 1] increased HAF and PVF. The plasma concentration level of PGE[sub 1] during the infusion of PGE[sub 1] was significantly higher at each dose in the cholestatic animals. These results suggest that the metabolism of PGE[sub 1] is attenuated by cholestasis. Plasma PGE[sub 1] concentrations should be useful in deciding the optimal dose of PGE[sub 1] .
- Subjects
PROSTAGLANDIN E1; REGIONAL blood flow; OBSTRUCTIONS of the bile ducts; BLOOD flow measurement; FLOW meters; CHOLESTASIS; THERAPEUTICS
- Publication
European Surgical Research, 1998, Vol 30, Issue 2, p115
- ISSN
0014-312X
- Publication type
Article