We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Replicating genotype–phenotype associations.
- Authors
Chanock, Stephen J.; Manolio, Teri; Boehnke, Michael; Boerwinkle, Eric; Hunter, David J.; Thomas, Gilles; Hirschhorn, Joel N.; Abecasis, Goncalo; Altshuler, David; Bailey-Wilson, Joan E.; Brooks, Lisa D.; Cardon, Lon R.; Daly, Mark; Donnelly, Peter; Fraumeni, Joseph F.; Freimer, Nelson B.; Gerhard, Daniela S.; Gunter, Chris; Guttmacher, Alan E.; Guyer, Mark S.
- Abstract
The article presents a replication study that evaluates the previous study on genotype-phenotype associations. The study concentrates on the initial discoveries which limit the plethora of false-positive results and determines the valid associations of genotype-phenotype. Three topics were addressed by the investigators, including the assessment of the validity and limitations of any genetic association, criteria for establishing the replication, and publication of high-quality association.
- Subjects
PHENOTYPES; PROTEOMICS; MOLECULAR biology; GENETICS; GENETIC mutation; REPLICATION (Experimental design)
- Publication
Nature, 2007, Vol 447, Issue 7145, p655
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/447655a