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- Title
Pathophysiological consequences of VEGF-induced vascular permeability.
- Authors
Weis, Sara M.; Cheresh, David A.
- Abstract
Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and ischaemic disease has unexpected pathophysiological consequences. By uncoupling endothelial cell–cell junctions VEGF causes vascular permeability and oedema, resulting in extensive injury to ischaemic tissues after stroke or myocardial infarction. In cancer, VEGF-mediated disruption of the vascular barrier may potentiate tumour cell extravasation, leading to widespread metastatic disease. Therefore, by blocking the vascular permeability promoting effects of VEGF it may be feasible to reduce tissue injury after ischaemic disease and minimize the invasive properties of circulating tumour cells.
- Subjects
PATHOLOGICAL physiology; CANCER; ISCHEMIA; VASCULAR endothelial growth factors; GROWTH factors; NEOVASCULARIZATION; METASTASIS; CANCER cells
- Publication
Nature, 2005, Vol 437, Issue 7058, p497
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature03987