We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Age and androgen-deprivation therapy on exercise outcomes in men with prostate cancer.
- Authors
Alberga, Angela; Segal, Roanne; Reid, Robert; Scott, Chris; Sigal, Ronald; Khandwala, Farah; Jaffey, James; Wells, George; Kenny, Glen
- Abstract
Purpose: The purpose of this study is to examine the effects of age (≤65 years or >65 years) and androgen-deprivation therapy (ADT, presence or absence) as factors that may predict changes in body composition and fitness following a 24-week exercise program in prostate cancer patients. Methods: One hundred twenty-one men were randomly allocated to either: (1) aerobic exercise (AE), (2) resistance exercise (RE), or (3) usual care (UC). Body composition was assessed by DXA. Aerobic fitness was assessed through a maximal treadmill test. Muscular strength was assessed by leg extension and bench press using the eight-repetition maximum test. Responses were compared between younger (≤65 years) and older (>65 years) patients with or without ADT. Results: There did not appear to be an interaction between age and ADT on body composition or fitness, nor were there any significant changes in body composition for participants ≤65 years. In participants aged >65 years, lean mass decreased in AE ( p = 0.013) and UC ( p = 0.006), but was preserved in RE. In participants receiving ADT, there was a decrease in lean mass in AE ( p = 0.003) and UC ( p < 0.001) but not in RE. The non-ADT group did not show any changes in body composition but did show improvements in muscular fitness following resistance training ( p < 0.001). Conclusion: Changes in body composition and physical fitness following a 24-week exercise program in men with prostate cancer are not influenced by age and/or ADT. Resistance training appears to attenuate the age-related decrease in lean mass and increase in body fat in older patients with prostate cancer and those receiving ADT.
- Subjects
ANDROGEN drugs; PROSTATE cancer treatment; AGE factors in human body composition; EXERCISE for men; PHYSICAL training &; conditioning; MUSCLE strength measurement; PHYSIOLOGY; THERAPEUTICS
- Publication
Supportive Care in Cancer, 2012, Vol 20, Issue 5, p971
- ISSN
0941-4355
- Publication type
Article
- DOI
10.1007/s00520-011-1169-x