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- Title
Comparative Analysis of the Pharmacological Activity of Bis(3,5-di-Tert-Butyl-4-Hydroxyphenylthiolate)Dimethylol in Different Modes of Administration on a Mouse Model of Melanoma B16 Tumor Growth.
- Authors
Dodokhova, M. A.; Kotieva, I. M.; Safronenko, A. V.; Alkhusein-Kulyaginova, M. S.; Sukhorukova, N. V.; Kotieva, V. M.; Kotieva, E. M.; Starostin, S. I.; Shpakovsky, D. B.; Nikitin, E. A.; Milaeva, E. R.
- Abstract
We performed a comparative analysis of the pharmacological activity of the hybrid organotin compound bis(3,5-di-tert-butyl-4-hydroxyphenylthiolate)dimethylol (Me-3) administered in different modes to mice with transplanted melanoma B16 to identify the most effective dosage regimen. Three modes of administration were used: preventive (before transplantation of tumor cells), classical according to Z. P. Sof'ina (48 h after transplantation of tumor cells), and delayed (7 days after transplantation of tumor cells, after formation of nodules of the primary tumor node). Compound Me-3 was administered at a total dose of 375 mg/kg intraperitoneally once a day for 5 days. The classical mode of administration was identified as the most effective, which indicates the preventive antimetastatic activity of Me-3 on the model of the transplanted mouse tumor melanoma B16.
- Subjects
TUMOR growth; LABORATORY mice; ANIMAL disease models; COMPARATIVE studies; ORGANOTIN compounds; MICE
- Publication
Bulletin of Experimental Biology & Medicine, 2022, Vol 173, Issue 5, p620
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-022-05599-9