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- Title
Comparison of the Effects of KE and AED Peptides on Functional Activity of Human Skin Fibroblasts during Their Replicative Aging.
- Authors
Fridman, N. V.; Linkova, N. S.; Kozhevnikova, E. O.; Gutop, E. O.; Khavinson, V. Kh.
- Abstract
We studied the effect of KE and AED peptides on the expression of sirtuin-1, sirtuin-6, collagen I, cytokines (IL-1, TGF-β), and transcription factor NF-κB in human skin fibroblasts during their replicative aging. Immunocytochemical analysis and confocal microscopy showed that KE peptide reduces the synthesis of factors of the inflammatory response IL-1, NF-κB, and TGF-β and stimulates the synthesis of sirtuin-6. KE peptide normalizes the immunological function of human skin fibroblasts during their aging. AED peptide activates the synthesis of sirtuin-1, sirtuin-6, and collagen I in human skin fibroblasts during their replicative aging, which attests to its geroprotective effect.
- Subjects
FIBROBLASTS; PEPTIDES; PEPTIDE synthesis; INFLAMMATION; DNA replication
- Publication
Bulletin of Experimental Biology & Medicine, 2020, Vol 170, Issue 1, p154
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-020-05022-1