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- Title
Growth-Stimulating Effect of Human Platelets Stabilized with Silver Nanoparticles.
- Authors
Makarov, M. S.; Storozheva, M. V.; Borovkova, N. V.; Ponomarev, I. N.
- Abstract
We studied proliferative activity of multipotent mesenchymal stromal cells on collagen matrices containing platelets stabilized with silver nanoparticles. Dose-dependent stimulation of the growth of stromal cells without their structural damage was observed in the presence of stabilized platelets in proportion of 20-120 mln per 105 multipotent mesenchymal stromal cells. The same doses of non-stabilized platelets produced less pronounced stimulation effect. In higher doses (≥180 mln) stabilized platelets inhibited cell proliferation and induced their damage. Stabilized platelets enhanced migration of multipotent mesenchymal stromal cells; after formation of the monolayer, they actively colonized deep layer of the collagen matrix. The formed monolayer of multipotent mesenchymal stromal cells survived over 14 days without appreciable cell damage.
- Subjects
BLOOD platelets; COLLAGEN; MESENCHYMAL stem cells; STROMAL cells; CELL proliferation
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 166, Issue 2, p260
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4328-y