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- Title
Immunocorrecting properties of GB-115 dipeptide.
- Authors
E. Shipaeva; L. Kovalenko; S. Khaidukov; L. Kolik; T. Gudasheva; A. Durnev; S. Seredenin
- Abstract
Abstract  We studied the effects of a new dipeptide with anxiolytic activity (GB-115, N-phenylhexanoyl-glycyl-L-tryptophan amide) on parameters of the immune in intact mice and in animals with secondary immunodeficiency caused by cyclophosphamide. GB-115 in doses of 0.1â10 mg/kg stimulated phagocytic activity of peritoneal macrophages and humoral immune response in intact mice. GB-115 exhibited immunocorrecting activity in animals with secondary immunodeficiency.
- Subjects
PEPTIDES; IMMUNODEFICIENCY; TRANQUILIZING drugs; LABORATORY mice; IMMUNE response; PHAGOCYTOSIS
- Publication
Bulletin of Experimental Biology & Medicine, 2008, Vol 145, Issue 5, p610
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-008-0153-z