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- Title
Mutational landscape of prostate tumors revealed by whole-exome sequencing.
- Authors
Gilyazova, I.; Yankina, M.; Kunsbaeva, G.; Klimentova, E.; Izmaylov, A.; Pavlov, V.; Khusnutdinova, E.
- Abstract
The results of the whole-exome DNA sequencing of eight prostate adenocarcinoma patients are presented. DNA was isolated from the peripheral blood as well as healthy and tumor prostate tissue from each patient. Bioinformatics analysis was conducted and the most significant mutations in prostate cancer patients were revealed. The obtained data could be important for understanding of the molecular mechanisms of prostate cancer pathogenesis and facilitate development of new approaches for treatment of the disease.
- Subjects
PROSTATE tumors; NUCLEOTIDE sequencing; PROSTATE tumors treatment; BLOOD cells; BIOINFORMATICS
- Publication
Russian Journal of Genetics, 2016, Vol 52, Issue 9, p999
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795416090052