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- Title
Research progress on the intervention of traditional Chinese medicine in IBS-D based on the "SCFAs-intestinal barrier" pathway.
- Authors
DOU Xin; HE Changhui; MEI Xiao; PAN Haidi; MA Yuanxin; WANG Wei
- Abstract
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a clinically common functional gastrointestinal disease, the "SCFAs-intestinal barrier" pathway plays an important role in the pathogenesis of IBS-D. Traditional Chinese medicine monomers/compounds or Chinese medicine compound can treat IBS-D by regulating the "SCFAs-intestinal barrier" through multiple pathways and multiple targets. This article takes the relationship between SCFAs and the four major intestinal barriers, as well as the mediating effect of IBS-D,as the starting point to systematically review and sort out the relevant literature on the targeted regulation of "SCFAs-intestinal barrier" in the treatment of IBS-D by Traditional Chinese medicine monomers/compounds and Chinese medicine compound; explores the theoretical basis of IBS-D caused by "SCFAs-intestinal barrier" from the perspective of "Large intes" tine dominating fluid", in order to provide ideas for Traditional Chinese medicine to establish a precision treatment system with Chinese medicine characteristics.
- Subjects
CHINESE medicine; IRRITABLE colon; GASTROINTESTINAL diseases
- Publication
Journal of Practical Medicine / Shiyong Yixue Zazhi, 2024, Vol 40, Issue 15, p2177
- ISSN
1006-5725
- Publication type
Article
- DOI
10.3969/j.issn.1006-5725.2024.15.023