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- Title
Mechanisms of the Anti-Infl ammatory and Antifi brotic Activity of a Sympatholytic Agent during Toxic Pulmonary Fibrosis.
- Authors
Skurikhin, E.; Khmelevskaya, E.; Pershina, O.; Andreeva, T.; Ermolaeva, L.; Krupin, V.; Ermakova, N.; Reztsova, A.; Stepanova, I.; Dygai, A.
- Abstract
The effect of a course treatment with a sympatholytic reserpine on the infl ammatory response and connective tissue proliferation in the lungs of C57Bl/6 mice was studied on the model of toxic pulmonary fi brosis induced by intratracheal administration of bleomycin. This sympatholytic reduced infi ltration of the alveolar interstitium and alveolar ducts with infl ammatory cells (lymphocytes, macrophages, neutrophils, and plasma cells) and prevented connective tissue proliferation in the lungs. The anti-infl ammatory effect of reserpine was associated with a decrease in activity of bone marrow granulocyte-erythroid-macrophage-megakaryocyte and granulocyte precursors (proliferation and mobilization). The antifi brotic effect of reserpine was due to a decrease in the number of committed precursors for mesenchymopoiesis.
- Subjects
SYMPATHOLYTIC agents; PULMONARY fibrosis; INFLAMMATION; IMMUNE response; EXPERIMENTAL pharmacology
- Publication
Bulletin of Experimental Biology & Medicine, 2012, Vol 153, Issue 5, p638
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-012-1786-5