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- Title
Induced pluripotent stem cells and reprogramming: seeing the science through the hype.
- Authors
Belmonte, Juan Carlos Izpisúa; Ellis, James; Hochedlinger, Konrad; Yamanaka, Shinya; Izpisúa Belmonte, Juan Carlos
- Abstract
No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.
- Subjects
EMBRYONIC stem cell research; SOMATIC cells; LABORATORY mice; CELL growth; CELL proliferation; ANIMALS; CELL differentiation; CELL physiology; STEM cells
- Publication
Nature Reviews Genetics, 2009, Vol 10, Issue 12, p878
- ISSN
1471-0056
- Publication type
review
- DOI
10.1038/nrg2700