We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Human genetic variation and its contribution to complex traits.
- Authors
Frazer, Kelly A.; Murray, Sarah S.; Schork, Nicholas J.; Topol, Eric J.
- Abstract
The last few years have seen extensive efforts to catalogue human genetic variation and correlate it with phenotypic differences. Most common SNPs have now been assessed in genome-wide studies for statistical associations with many complex traits, including many important common diseases. Although these studies have provided new biological insights, only a limited amount of the heritable component of any complex trait has been identified and it remains a challenge to elucidate the functional link between associated variants and phenotypic traits. Technological advances, such as the ability to detect rare and structural variants, and a clear understanding of the challenges in linking different types of variation with phenotype, will be essential for future progress.
- Subjects
HUMAN genetic variation; PHENOTYPES; GENOMICS; GENETIC polymorphisms; NUCLEOTIDES; DISEASE susceptibility; DOCUMENTATION; GENETICS; HUMAN genome; SEQUENCE analysis; GENOTYPES
- Publication
Nature Reviews Genetics, 2009, Vol 10, Issue 4, p241
- ISSN
1471-0056
- Publication type
journal article
- DOI
10.1038/nrg2554