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- Title
A nationwide questionnaire survey on the prevalence of ankylosing spondylitis and non-radiographic axial spondyloarthritis in Japan.
- Authors
Yuri Matsubara; Yosikazu Nakamura; Naoto Tamura; Hideto Kameda; Kotaro Otomo; Mitsumasa Kishimoto; Yuho Kadono; Shigeyoshi Tsuji; Tatsuya Atsumi; Hiroaki Matsuno; Michiaki Takagi; Shigeto Kobayashi; Keishi Fujio; Norihiro Nishimoto; Nami Okamoto; Ayako Nakajima; Kiyoshi Matsui; Masahiro Yamamura; Yasuharu Nakashima; Atsushi Kawakami
- Abstract
Objective: This nationwide study aimed to reveal the prevalence of ankylosing spondylitis (AS), non-radiographic axial spondyloarthritis (nr-ax SpA), and the positivity rate of human leukocyte antigen (HLA) among such patients in Japan. Methods: The first survey was conducted in 2221 randomly selected facilities (26.3%) in September 2018, where the patients with AS/nr-ax SpA were taken care of from January to December 2017. We estimated the total number of these patients using response and extraction rates. A second survey was conducted in 117 facilities (49.8%) to assess for HLA-B27 positivity rate and clinical features. Results: The estimated total numbers of the patients with AS and nr-ax SpA were 3200 (95% confidence interval [CI]: 2400-3900) and 800 (530-1100), suggesting that the prevalence values of AS and nr-ax SpA in general population were 2.6/100,000 (0.0026%) and 0.6/100,000 (0.0006%), respectively. Although 55.5% (76/137) of patients with AS were HLA-B27-positive, those whose age of onset was estimated to be over 50 years tended to undergo less HLA-B27 testing. Conclusion: This study revealed the lower prevalence of AS/nr-ax SpA in Japan, compared to those in other countries. Further studies are required to reveal the association of HLA-B27 with the clinical features.
- Subjects
JAPAN; ANKYLOSING spondylitis; SPONDYLOARTHROPATHIES; QUESTIONNAIRES
- Publication
Modern Rheumatology, 2022, Vol 32, Issue 5, p960
- ISSN
1439-7595
- Publication type
Article
- DOI
10.1093/mr/roab096