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- Title
ANTICANCER EFFECTS OF COMBINED PHOTOBIOMODULATION, CARBOPLATIN, CASSIA FISTULA SEEDS EXTRACT AND GOLD NANOPARTICLES (AUNPS) ON PROSTATE CANCER CELL LINE (PC3).
- Authors
Ghaleb, Rana A.; Obayes, Sarah k.; Sahib, Zena Hasan
- Abstract
Although, chemotherapy still the main mode for managing cancer but its usage is limited by resistance and adverse effects which are depend on the dose. Other modes or techniques such as LASER irradiation, anti-cancer plant or nanometals particles can be used to solve this problem. In this study, we use three different agents (carboplatin, cassia fistula seed extract, and gold nanoparticles) where the cytotoxicity of them was investigated on prostate cancer (PC3) cell line. The PC3 cells were exposed to six doses for each of carboplatin, cassia fistula fruits extract, and gold nanoparticles. Then for each agent, the dose that gave significant decrease in the viability percent was used in combination with a constant dose of He-Ne laser (635 nm). From the results, we found that the inhibition percent was increased by the combination therapy as compared to the monotherapy for each agent. Also, the highest inhibition percent was observed in the combination of gold nanoparticles and 191 J/cm2 laser. In a conclusion, LAESR is an amazing technique to increase the cytotoxicity of the classical and non-classical methods for treating cancer especially its use in combination with gold nano-particles in the photo-thermal technique.
- Subjects
PHOTOBIOMODULATION therapy; CARBOPLATIN; CASSIA fistula; SEEDS; GOLD nanoparticles; PROSTATE cancer
- Publication
Biochemical & Cellular Archives, 2021, Vol 21, Issue 2, p4105
- ISSN
0972-5075
- Publication type
Article