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- Title
SOME GENERAL CHARACTERISTICS, HISTOLOGICAL AND SEROLOGICAL ASPECTS IN IRAQI CHILDREN WITH CELIAC DISEASE.
- Authors
Ali, Hiba Mohssin; Al-Assaf, Anwar I. S.
- Abstract
Celiac disease is an autoimmune disease caused by dietary proteins such as gluten (gliadin) in wheat and barley, which affects the small intestine and occurs in individuals with genetic predisposition. Thirty Iraqi Arabs celiac children (18 females and 12 males) were diagnosed and confirmed by intestinal endoscopy, their age ranged between 3-15 year, In addition, 20 healthy children (controls) randomly selected from healthy children with matched ages to patients. Our objective is to evaluate the clinical and laboratory characteristics of celiac patients and their relationship to Marsh classification. Association between age, weight, height and body mass index (BMI) were studied well as the results of histological examination for intestinal endoscopy were interpreted. ELISA technique was used to detect antibodies directed against anti-gliadin IgA (AGA), anti-tissue transglutaminase IgA (tTG) and IL-1b in study groups. The results showed that the incidence of disease was observed in females more than male with no significant difference (P >0.05) also mean of BMI, weight and height in patients was lower than the mean in control group with a high significant difference (P£0.05). The highest frequency of patients was in close relatives parents followed by in non-relative parents with a high significant differences (P>0.05). The occurrence of disease in children with a family history of the disease was much higher (P£0.05) and there was a high incidence of celiac disease in children whose parents are relatives of the first degree, as well as in the children having a family history of genetic diseases especially; CD, diabetes and thyroidism. The study showed a high percentage for diabetes (p£0.05), which revealed a strong genetic link between diabetes and thyroidism with CD. Based on Marsh’s classification, results shown that the majority of patients had partial villous atrophy (Marsh III A), followed by subtotal and total villous atrophy (Marsh III B and III C, respectively). High significant difference of (AGA) and (tTG) were observed in celiac patients compared to control group (p£0.05). While there was no significant variation in IL-1â serum level between celiac children and control group (P>0.05). tTG IgA seropositivity is associated with more severe disease. Anti-tTG IgA showed a high significant difference (P£0.05) with gradual increase in the level of bowel damage classified by Marsh (Marsh IIIA, 202.5±345.6 U/ml; Marsh IIIB, 382.5±255.5 U/ml and Marsh IIIC 939.4±1022.8 U/ml). Positive correlation was found between anti-tTG levels and modified Marsh grading.
- Subjects
CELIAC disease in children; DIETARY proteins; BODY mass index; TRANSGLUTAMINASES; ENZYME-linked immunosorbent assay
- Publication
Biochemical & Cellular Archives, 2020, Vol 20, Issue 1, p2081
- ISSN
0972-5075
- Publication type
Article
- DOI
10.35124/bca.2020.20.1.2081