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- Title
The dawning era of polymer therapeutics.
- Authors
Duncan, Ruth
- Abstract
As we enter the twenty-first century, research at the interface of polymer chemistry and the biomedical sciences has given rise to the first nano-sized (5-100 nm) polymer-based pharmaceuticals, the 'polymer therapeutics'. Polymer therapeutics include rationally designed macromolecular drugs, polymer-drug and polymer-protein conjugates, polymeric micelles containing covalently bound drug, and polyplexes for DNA delivery. The successful clinical application of polymer-protein conjugates, and promising clinical results arising from trials with polymer-anticancer-drug conjugates, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
- Subjects
POLYMERIC drugs; BIOCONJUGATES
- Publication
Nature Reviews Drug Discovery, 2003, Vol 2, Issue 5, p347
- ISSN
1474-1776
- Publication type
Article
- DOI
10.1038/nrd1088