We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Putting chirality to work: the strategy of chiral switches.
- Authors
Agranat, Israel; Caner, Hava; Caldwell, John
- Abstract
Most of the new drugs reaching the market today are single enantiomers, rather than the racemic mixtures that dominated up to ten years ago. Many of the new single-enantiomer drugs were developed as such, but there are also important examples of new single-enantiomer drugs derived from 'chiral switches' of established racemates. Indeed, a well-timed chiral switch can offer enhanced therapy and further profitability as a 'line extension' of a major racemic drug with patents that are expiring.
- Subjects
CHIRALITY; DRUG development
- Publication
Nature Reviews Drug Discovery, 2002, Vol 1, Issue 10, p753
- ISSN
1474-1776
- Publication type
Article
- DOI
10.1038/nrd915