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- Title
Xanthophyll supplementation reduced inflammatory mediators and apoptosis in hens and chicks.
- Authors
Gao, Y.-Y.; Jin, L.; Ji, J.; Sun, B.-L.; Xu, L.-H.; Wang, Q.-X.; Wang, C.-K.; Bi, Y.-Z.
- Abstract
This study investigated effects of xanthophylls (containing 40% lutein and 60% zeaxanthin) on gene expression of inflammatory mediators (cyclooxygenase-2 [COX-2] and induced nitric oxide synthase [iNOS]) and apoptosis (B cell lymphoma/leukemia-2 [Bcl-2] and caspase-3) of breeding hens and chicks. In Exp. 1, 432 hens were divided into 3 groups and fed diets supplemented with 0 (as the control group), 20, or 40 mg/kg xanthophylls. The liver, duodenum, jejunum, and ileum were sampled after 35 d. Results showed that 40 mg/kg of xanthophyll addition decreased COX-2 in the liver, iNOS in the liver and duodenum, and caspase-3 in the liver and jejunum while increasing Bcl-2 level in the liver and jejunum. Experiment 2 was a 2 x 2 factorial design. Male chicks hatched from hens fed 0 or 40 mg/kg xanthophyll diets were fed diets containing either 0 or 40 mg/kg xanthophylls. The liver, duodenum, jejunum, and ileum were sampled at 0, 7, 14, and 21 d after hatching. Results showed that in ovo xanthophylls reduced inflammatory mediators and apoptosis in the liver, duodenum, and jejunum of chicks mainly within 1 wk after hatching, whereas dietary xanthophylls only decreased iNOS expression in the liver from 2 wk onward. These results underlined important anti-inflammatory and antiapoptotic effects of maternal but not progeny dietary xanthophylls. In conclusion, xanthophylls can suppress inflammatory mediators and apoptosis in different tissues of hens and chicks.
- Subjects
XANTHOPHYLLS; DIETARY supplements; INFLAMMATORY mediators; APOPTOSIS; POULTRY feeding; HENS
- Publication
Journal of Animal Science, 2016, Vol 94, Issue 5, p2014
- ISSN
0021-8812
- Publication type
Article
- DOI
10.2527/jas.2015-9628