We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Direct demonstration of reduction of the output of the human motor cortex induced by a fatiguing muscle contraction.
- Authors
Di Lazzaro, V.; Oliviero, A.; Tonali, P. A.; Mazzone, P.; Insola, A.; Pilato, F.; Saturno, E.; Dileone, M.; Rothwell, J. C.
- Abstract
A brief period of strong muscle contraction suppresses the amplitude of EMG responses evoked in relaxed muscle by transcranial magnetic stimulation (TMS) of the contralateral motor cortex. Here we investigate this phenomenon in more detail by recording the descending motor volleys evoked by TMS from electrodes in the cervical epidural space of three conscious patients implanted with chronic electrical stimulators for control of pain. We confirm that fatigue suppresses I waves evoked by TMS. In addition, D waves were suppressed in two of the patients, suggesting that axonal excitability might also be compromised by a period of intense muscle contraction.
- Subjects
BRAIN research; MOTOR cortex; FRONTAL lobe; CEREBRAL cortex; NEUROPHYSIOLOGY; NEUROLOGY; MUSCLE contraction
- Publication
Experimental Brain Research, 2003, Vol 149, Issue 4, p535
- ISSN
0014-4819
- Publication type
Article
- DOI
10.1007/s00221-003-1408-6