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- Title
A Self-Assembling Pfs230D1-Ferritin Nanoparticle Vaccine Has Potent and Durable Malaria Transmission-Reducing Activity.
- Authors
Salinas, Nichole D.; Ma, Rui; McAleese, Holly; Ouahes, Tarik; Long, Carole A.; Miura, Kazutoyo; Lambert, Lynn E.; Tolia, Niraj H.
- Abstract
Malaria is caused by eukaryotic protozoan parasites of the genus Plasmodium. There are 249 million new cases and 608,000 deaths annually, and new interventions are desperately needed. Malaria vaccines can be divided into three categories: liver stage, blood stage, or transmission-blocking vaccines. Transmission-blocking vaccines prevent the transmission of disease by the mosquito vector from one human to another. Pfs230 is one of the leading transmission-blocking vaccine antigens for malaria. Here, we describe the development of a 24-copy self-assembling nanoparticle vaccine comprising domain 1 of Pfs230 genetically fused to H. pylori ferritin. The single-component Pfs230D1-ferritin construct forms a stable and homogenous 24-copy nanoparticle with good production yields. The nanoparticle is highly immunogenic, as two low-dose vaccinations of New Zealand White rabbits elicited a potent and durable antibody response with high transmission-reducing activity when formulated in two distinct adjuvants suitable for translation to human use. This single-component 24-copy Pfs230D1-ferritin nanoparticle vaccine has the potential to improve production pipelines and the cost of manufacturing a potent and durable transmission-blocking vaccine for malaria control.
- Subjects
NANOPARTICLES; MALARIA vaccines; MALARIA; MOSQUITO vectors; MALARIA prevention; HELICOBACTER pylori infections; TRICHOMONIASIS
- Publication
Vaccines, 2024, Vol 12, Issue 5, p546
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines12050546