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- Title
Autoreactive CD8-specific T-cell response in primary biliary cirrhosis.
- Authors
Kita, Hiroto
- Abstract
Primary biliary cirrhosis (PBC) is an autoimmune liver disease of unknown etiology. Autoimmune attack in PBC is predominantly organ-specific, despite the presence of mitochondrial autoantigens, the major targets of autoimmunity in PBC, in all nucleated cells. Cytotoxic T lymphocytes are thought to be directly involved in the tissue injury in PBC. The major histocompatibility complex (MHC) class I-restricted epitope for E2 components of pyruvate dehydrogenase complexes, namely amino acid 159–167, a region very close to the epitoperecognized by MHC class II-restricted CD4 cells and by antibody, has been characterized. In addition, there was a 10-fold increase in the frequency of autoreactive cytotoxic T lymphocytes in the liver as compared to the blood in PBC patients using tetramer technology.
- Subjects
T cells; LYMPHOCYTES; BILIOUS diseases &; biliousness; BILIARY fistula; CIRRHOSIS of the liver
- Publication
Hepatology Research, 2007, Vol 37, pS402
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1111/j.1872-034X.2007.00238.x