We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinico-radiological features of primary lacrimal gland pleomorphic adenoma: an analysis of 37 cases.
- Authors
Watanabe, Akihide; Andrew, Nicholas; Ueda, Kosuke; Kinoshita, Shigeru; Katori, Nobutada; Reid, Michael; Pirbhai, Adnan; Selva, Dinesh
- Abstract
Purpose: To present the radiological and clinical features of primary lacrimal gland pleomorphic adenoma (PLGPA). Methods: Thirty-seven consecutive PLGPAs presenting to two hospitals in Japan were reviewed. Results: PLGPA cases had 15 men and 22 women with a mean age of 51.9 years. Common presenting features were ptosis (83 %), diplopia (78 %) and globe displacement (78 %). Twenty-two percent of cases reported symptom duration of less than 6 months, but only 5.6 % of cases had pain. Sixteen percent of PLGPAs were centered in the palpebral lobe; none of which were associated with globe indentation or lacrimal fossa expansion. Bony excavation was observed in 84 % of orbital lobe PLGPA; the bone margin was well demarcated and the character of excavation was more frequently smooth than scalloped (2:1). The presence of globe indentation or bony excavation was associated with increased tumor size ( p = 0.003). An enhancing rim was visible on T1-weighted fat-suppressed gadolinium-enhanced magnetic resonance imaging (T1FS-Gad MRI) in 27 %. Five (19 %) enclosed cystic spaces were bright on T2-weighted MRI and non-enhancing. Calcification of tumor parenchyma was common in cystic cases but rare in non-cystic cases ( p = 0.01). Conclusions: PLGPAs have varied clinical and radiological features. Common radiological features are a heterogeneous internal architecture on T2-weighted MRI, an enhancing rim on T1FS-Gad MRI, smooth or scalloped bony excavation with intact cortical bone, and globe indentation. Cystic spaces, calcification, and symptom duration less than 6 months are common, but pain is rare. Awareness of the clinico-radiological variants of PLGPA is important when considering incisional biopsy of a lacrimal gland mass.
- Subjects
LACRIMAL apparatus; POLYMORPHISM (Crystallography); ADENOMA; FIBROADENOMAS; BIOPSY
- Publication
Japanese Journal of Ophthalmology, 2016, Vol 60, Issue 4, p286
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-016-0451-3